Solute carrier family 38 member 9

SLC38A9
Identifiers
Aliases	SLC38A9, URLC11, solute carrier family 38 member 9
External IDs	MGI: 1918839 HomoloGene: 18139 GeneCards: SLC38A9
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	55,773,194 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	112,738,749 bp[2]
Gene ontology
Molecular function	• protein binding; • amino acid transmembrane transporter activity;
Cellular component	• integral component of membrane; • endosome; • Ragulator complex; • late endosome; • lysosome; • membrane; • late endosome membrane; • nucleoplasm; • intracellular membrane-bounded organelle; • lysosomal membrane;
Biological process	• cellular response to amino acid stimulus; • amino acid transmembrane transport; • amino acid transport; • positive regulation of TOR signaling; • cell cycle arrest; • regulation of macroautophagy;
	Sources:Amigo / QuickGO
Orthologs
	153129
	268706
	ENSG00000177058
	ENSMUSG00000047789
	Q8NBW4
	Q8BGD6
NM_001258286; NM_001258287; NM_001282429; NM_173514; NM_001349382;
	NM_001349383; NM_001349384; NM_001349385
	NM_175376; NM_178746
NP_001245215; NP_001245216; NP_001269358; NP_775785; NP_001336311;
	NP_001336312; NP_001336313; NP_001336314
	NP_848861
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 38 member 9 is a protein that in humans is encoded by the SLC38A9 gene. ^[5]

References

Uchiyama K, Takagi T, Iwamoto Y, Kondo N, Okayama T, Yoshida N, Kamada K, Katada K, Handa O, Ishikawa T, Yasuda H, Sakagami J, Konishi H, Yagi N, Naito Y, Itoh Y (2014). "New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid". PLoS ONE. 9 (4): e95080. doi:10.1371/journal.pone.0095080. PMC 3999094. PMID 24762746.
Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G (March 2015). "SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1". Nature. 519 (7544): 477–81. doi:10.1038/nature14107. PMC 4376665. PMID 25561175.
Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM (January 2015). "Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1". Science. 347 (6218): 188–94. doi:10.1126/science.1257132. PMC 4295826. PMID 25567906.
Jung J, Genau HM, Behrends C (July 2015). "Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9". Mol. Cell. Biol. 35 (14): 2479–94. doi:10.1128/MCB.00125-15. PMC 4475919. PMID 25963655.

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