Isoniazid/rifampicin

Isoniazid/rifampicin
Combination of
Isoniazid Anti-tuberculosis medication
Rifampicin Anti-tuberculosis medication
Clinical data
Trade names IsonaRif, Rifamate, others
Pregnancy
category
  • US: C (Risk not ruled out)
    ATC code

    Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat tuberculosis.[1] It is a fixed dose combination of isoniazid and rifampicin (rifampin).[1] It is used together with other antituberculosis medication.[1] It is taken by mouth.[1]

    Side effects are those of the underlying medications.[1] Common side effects include poor coordination, poor appetite, nausea, numbness, and feeling tired.[2] More severe side effects include liver problems.[2] Use is generally not recommended in children.[1] It is unclear if use is safe in pregnancy.[3]

    It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[4] The wholesale cost in the developing world is about 5.10 USD a month.[5] In the United Kingdom a month of medication costs the NHS about 28.11 pounds.[6]

    References

    1. 1 2 3 4 5 6 WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 142. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
    2. 1 2 "Isoniazid/rifampin Side Effects in Detail - Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
    3. ↑ "Isoniazid / rifampin Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
    4. ↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
    5. ↑ "Rifampicin + Isoniazid". International Drug Price Indicator Guide. Retrieved 8 December 2016.
    6. ↑ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 403. ISBN 9780857111562.
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