Reticulocalbin 2

RCN2
Identifiers
AliasesRCN2, E6BP, ERC-55, ERC55, TCBP49, reticulocalbin 2
External IDsMGI: 1349765 HomoloGene: 2176 GeneCards: RCN2
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q24.3Start76,931,619 bp[1]
End76,954,392 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5955

26611

Ensembl

ENSG00000117906

ENSMUSG00000032320

UniProt

Q14257

Q8BP92

RefSeq (mRNA)

NM_002902
NM_001271837

NM_001278274
NM_011992

RefSeq (protein)

NP_001258766
NP_002893

NP_001265203
NP_036122

Location (UCSC)Chr 15: 76.93 – 76.95 MbChr 9: 56.04 – 56.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Reticulocalbin-2 is a protein that in humans is encoded by the RCN2 gene.[5][6][7]

Reticulocalbin 2 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. The RCN2 gene maps to the same region as type 4 Bardet-Biedl syndrome (MIM:600374), suggesting a possible causative role for reticulocalbin 2 in the disorder.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000117906 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032320 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Wang JY, Zhen DK, Bianchi DW, Androphy EJ, Chen JJ (Apr 1998). "Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33→q24.1 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 60–1. doi:10.1159/000134683. PMID 9533013.
  6. ↑ Chen JJ, Reid CE, Band V, Androphy EJ (Aug 1995). "Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein". Science. 269 (5223): 529–31. doi:10.1126/science.7624774. PMID 7624774.
  7. 1 2 "Entrez Gene: RCN2 reticulocalbin 2, EF-hand calcium binding domain".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068.
  • Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi:10.1074/jbc.272.34.21488. PMID 9261167.
  • Weis K, Griffiths G, Lamond AI (1994). "The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif". J. Biol. Chem. 269 (29): 19142–50. PMID 8034671.


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