Pyruvate decarboxylation

Pyruvate decarboxylation or pyruvate oxidation is the conversion of pyruvate into acetyl-CoA (activated acetate) by the enzyme pyruvate dehydrogenase.[1][2]

Pyruvate dehydrogenase complex reaction

The reaction is:

1 pyruvate + 1 NAD+ + CoA → 1 acetyl-CoA + NADH + CO2 + H+

Pyruvate oxidation is the step that connects glycolysis and the Krebs cycle. Since in glycolysis a glucose molecule (6 carbons) is split into 2 pyruvates (3 carbons each), this process happens twice for every glucose. The 2 acetyl-CoA can then enter the Krebs cycle.

Pyruvate dehydrogenase is an enzyme complex which contains- TPP (thiamine pyrophosphate), lipoic acid, decarboxylase, transacetylase and Mg2+ ions.

References

  1. ↑ "Pyruvate oxidation". Khanacademy.org. Retrieved 25 January 2018.
  2. ↑ "Pyruvate Oxidation". Oregonstate.edu. Retrieved 25 January 2018.


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