Phthalide
Names | |
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IUPAC name
2-Benzofuran-1(3H)-one | |
Other names
Phthalolactone | |
Identifiers | |
3D model (JSmol) |
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ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.001.586 |
PubChem CID |
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UNII | |
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Properties | |
C8H6O2 | |
Molar mass | 134.13 g·mol−1 |
Melting point | 75 to 77 °C (167 to 171 °F; 348 to 350 K)[1] |
Boiling point | 290 °C (554 °F; 563 K)[2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Phthalide is an organic chemical compound with the molecular formula C8H6O2. It is a lactone that serves as the core chemical structure for a variety of more complex chemical compounds including dyes (such as phenolphthalein), fungicides (such as tetrachlorophthalide, often referred to simply as "phthalide"), and natural oils (such as butylphthalide).
Uses
Phthalide is used in the synthesis of several pharmaceutical drugs including isoxepac, vatalanib, and hydralazine as well as the pesticide kresoxim-methyl.
Examples
- Phenolphthalein
- Tetrachlorophthalide
References
- ↑ Kumar, R. Arun; Maheswari, C. Uma; Ghantasala, Satheesh; Jyothi, C.; Reddy, K. Rajender (2011). "Synthesis of 3H-Quinazolin-4-ones and 4H-3,1-Benzoxazin-4-ones via Benzylic Oxidation and Oxidative Dehydrogenation using Potassium Iodide-tert-Butyl Hydroperoxide". Advanced Synthesis & Catalysis. 353 (2+3): 401–410. doi:10.1002/adsc.201000580.
- ↑ Kus, Nermin Simsek (2008). "Some oxidation reactions with molecular oxygen in subcritical water". Asian Journal of Chemistry. 20 (2): 1226–1230.
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