Spider lamb syndrome

Spider lamb syndrome, also known as spider syndrome[1] and more formally as ovine hereditary chondrodysplasia,[2] is a homozygous recessive disorder affecting the growth of cartilage and bone in sheep. It is a semilethal trait,[3] which is thought to have been first observed in the 1970s,[4] and is most common in sheep of the Suffolk and Hampshire breeds.[5] The mutation which causes spider lamb syndrome is found on ovine chromosome 6,[6] and involves the inactivation of fibroblast growth factor receptor 3.[7]

Afflicted animals may be visibly deformed at birth and unable to stand, or seemingly normal for the first 4 to 6 weeks of their lives.[3]

The name derives from the limbs of afflicted animals being thin, elongated, and "spider-like".[8]

References

  1. ↑ Hereditary chondrodysplasia ("spider syndrome") in a New Zealand Suffolk lamb of American origin., originally published in New Zealand veterinary journal, Volume 43, p.118-22 (1995); by West, DM; Burbidge, H M; Vermunt, J J; Arthur, D G; archived at the International Sheep Research Centre; retrieved July 19, 2012
  2. ↑ Developmental progression of the Spider Lamb Syndrome in Small Ruminant Research, Volume 18, Issue 2 , Pages 179-184, October 1995, by A.M. Oberbauer, N.E. East, R. Pool, J.D. Rowe, and R.H. BonDurant
  3. 1 2 Spider Lamb Syndrome: Introduction at UC Davis School of Veterinary Medicine; retrieved July 19, 2012
  4. ↑ Spider Lamb Syndrome - 1998 Sheep Day Report: The Test for Spider Lamb Syndrome Gene in Sheep at North Dakota State University; by Bert Moore, Wes Limesand and Paul Berg; publisher 1998; retrieved July 19, 2012
  5. ↑ Spider Lamb Syndrome, at the Merck Veterinary Manual; published 2011; retrieved July 19, 2012
  6. ↑ Localization of the locus causing Spider Lamb Syndrome to the distal end of ovine Chromosome 6, from Mammalian Genome 10, 35–38 (1999); by N.E. Cockett,T.L. Shay, J.E. Beever, D. Nielsen, J. Albretsen, M. Georges, K. Peterson, A. Stephens, W. Vernon, O. Timofeevskaia, S. South, J. Mork, A. Maciulis, T.D. Bunch; archived at the University of Liège; retrieved July 19, 2012
  7. ↑ Enhanced skeletal growth of sheep heterozygous for an inactivated fibroblast growth factor receptor 3, Journal of Animal Science, vol. 84 no. 11 2942-2949; by L. B. Smith, M. R. Dally, R. D. Sainz, K. L. Rodrigue and A. M. Oberbauer
  8. ↑ Toydemir RM, Brassington AE, Bayrak-Toydemir P, Krakowiak PA, Jorde LB, Whitby FG, Longo N, Viskochil DH, Carey JC, Bamshad MJ (2006). "A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome". Am J Hum Genet. 79: 935–41. doi:10.1086/508433. PMC 1698566. PMID 17033969.
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