Nifurtimox/eflornithine

Nifurtimox/eflornithine
Combination of
Nifurtimox antiparasitic agent
Eflornithine antiparasitic agent

Nifurtimox/eflornithine is a combination of two antiparasitic drugs, nifurtimox and eflornithine, used in the treatment of African trypanosomiasis (sleeping sickness).[1][2] It is included in the World Health Organization's Model List of Essential Medicines.[3]

A treatment regimen known as nifurtimox-eflornithine combination treatment (NECT) is used in second stage gambiense African trypanosomiasis throughout Africa where the disease is endemic.[4] The regimen involves slow infusion of 400 mg of eflornithine every 12 hours for 7 days combined with 15 mg/kg of nifurtimox orally three times a day for 10 days.[4]

References

  1. ↑ Priotto, Gerardo; Kasparian, Serena; Mutombo, Wilfried; Ngouama, Daniel; Ghorashian, Sara; Arnold, Ute; Ghabri, Salah; Baudin, Elisabeth; Buard, Vincent; Kazadi-Kyanza, Serge; Ilunga, Médard; Mutangala, Willy; Pohlig, Gabriele; Schmid, Caecilia; Karunakara, Unni; Torreele, Els; Kande, Victor (2009). "Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: A multicentre, randomised, phase III, non-inferiority trial". The Lancet. 374 (9683): 56. doi:10.1016/S0140-6736(09)61117-X.
  2. ↑ Alirol, Emilie; Schrumpf, David; Amici Heradi, Josué; Riedel, Andrea; De Patoul, Catherine; Quere, Michel; Chappuis, François (2013). "Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières Experience in the Democratic Republic of the Congo". Clinical Infectious Diseases. 56 (2): 195. doi:10.1093/cid/cis886. PMID 23074318.
  3. ↑ "Nifurtimox-eflornithine combination treatment for sleeping sickness (human African trypanosomiasis): WHO wraps up training of key health care personnel". World Health Organization. March 23, 2010.
  4. 1 2 Franco, Jose; Pere, Simarro; Diarra; Ruiz-Postigo; Samo; Jannin (2012). "Monitoring the use of nifurtimox-eflornithine combination therapy (NECT) in the treatment of second stage gambiense human African trypanosomiasis" (PDF). Research and Reports in Tropical Medicine: 93. doi:10.2147/RRTM.S34399.
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