Neamine

Neamine

Clinical data
Synonyms	Neomycin A
Identifiers
IUPAC name (1R,2R,3S,4R,6S)-4,6-Diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside
CAS Number	3947-65-7
PubChem CID	72392
DrugBank	DB04808
ChemSpider	65325
Chemical and physical data
Formula	C12H26N4O6
Molar mass	322.358 g/mol
3D model (JSmol)	Interactive image
SMILES O([C@H]1[C@H](O)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2N)CN
InChI InChI=1S/C12H26N4O6/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h3-12,17-20H,1-2,13-16H2/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/m1/s1 Key:SYJXFKPQNSDJLI-HKEUSBCWSA-N

Neamine (neomycin A) is a degradation product of the aminoglycoside antibiotic neomycin.

Further reading

• Zimmermann, L.; Bussière, A.; Ouberai, M.; Baussanne, I.; Jolivalt, C.; Mingeot-Leclercq, M. P.; Décout, J. L. (2013). "Tuning the Antibacterial Activity of Amphiphilic Neamine Derivatives and Comparison to Paromamine Homologues". Journal of Medicinal Chemistry. 56 (19): 7691–7705. doi:10.1021/jm401148j. PMID 24083676.