NUDT11

NUDT11
Identifiers
Aliases	NUDT11, APS1, ASP1, DIPP3b, DIPP3beta, hDIPP3beta, nudix hydrolase 11
External IDs	MGI: 1930957 HomoloGene: 86995 GeneCards: NUDT11
EC number	3.6.1.60
Gene location (Human)
Chr.	X chromosome (human)[1]
End	51,496,596 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	6,055,110 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity; • inositol diphosphate tetrakisphosphate diphosphatase activity; • inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; • hydrolase activity; • metal ion binding; • inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity; • inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity; • inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; • inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity; • inositol diphosphate pentakisphosphate diphosphatase activity; • inositol bisdiphosphate tetrakisphosphate diphosphatase activity; • endopolyphosphatase activity; • diphosphoinositol-polyphosphate diphosphatase activity; • bis(5'-adenosyl)-hexaphosphatase activity; • bis(5'-adenosyl)-pentaphosphatase activity; • m7G(5')pppN diphosphatase activity;
Cellular component	• intracellular; • cell nucleus; • cytoplasm; • cytosol;
Biological process	• inositol phosphate metabolic process; • diphosphoinositol polyphosphate metabolic process; • diadenosine pentaphosphate catabolic process; • diadenosine hexaphosphate catabolic process; • adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	55190
	58242
	ENSG00000196368
	ENSMUSG00000073295
	Q96G61
	P0C027; P0C028
	NM_018159
	NM_021431
	NP_060629
	NP_001026834; NP_067406; NP_001026834.1; NP_067406.2; NP_067406
	Wikidata
View/Edit Human	View/Edit Mouse

Diphosphoinositol polyphosphate phosphohydrolase 3-beta is an enzyme that in humans is encoded by the NUDT11 gene.^[5]^[6]

NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002).[supplied by OMIM]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196368 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073295 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hidaka K, Caffrey JJ, Hua L, Zhang T, Falck JR, Nickel GC, Carrel L, Barnes LD, Shears SB (Sep 2002). "An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase". J Biol Chem. 277 (36): 32730–8. doi:10.1074/jbc.M205476200. PMID 12105228.
1 2 "Entrez Gene: NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Leslie NR, McLennan AG, Safrany ST (2002). "Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases". BMC Biochem. 3: 20. doi:10.1186/1471-2091-3-20. PMC 117780. PMID 12121577.
Fisher DI, Safrany ST, Strike P, et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi:10.1074/jbc.M209795200. PMID 12370170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196368 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073295 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid12105228-5] Hidaka K, Caffrey JJ, Hua L, Zhang T, Falck JR, Nickel GC, Carrel L, Barnes LD, Shears SB (Sep 2002). "An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase". J Biol Chem. 277 (36): 32730–8. doi:10.1074/jbc.M205476200. PMID 12105228.

[entrez-6] 1 2 "Entrez Gene: NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11".

NUDT11

References

Further reading