''N,N'''-Diisopropylcarbodiimide
Identifiers | |
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3D model (JSmol) |
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Abbreviations | DIC, DIPC |
ChemSpider | |
ECHA InfoCard | 100.010.677 |
PubChem CID |
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Properties | |
C7H14N2 | |
Molar mass | 126.20 g·mol−1 |
Appearance | Liquid |
Density | 0.806 g/mL |
Boiling point | 145 to 148 °C (293 to 298 °F; 418 to 421 K) |
Hazards | |
Safety data sheet | External MSDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
N,N′-Diisopropylcarbodiimide is a carbodiimide used in peptide synthesis. As a liquid, it is easier to handle than the commonly used N,N′-dicyclohexylcarbodiimide, a waxy solid. In addition, N,N'-diisopropylurea, the byproduct of its use in many chemical reactions, is soluble in most organic solvents, a property that facilitates work-up.
Further reading
- Angell, Y (1994). "Comparative studies of the coupling of N-methylated, sterically hindered amino acids during solid-phase peptide synthesis". Tetrahedron Lett. 35 (33): 5981. doi:10.1016/0040-4039(94)88054-9.
- Izdebski, JAN; Orlowska, Alicja; Anulewicz, Romana; Witkowska, EWA; Fiertek, Dariusz (1994). "Reinvestigation of the reactions of carbodiimides with alkoxycarbonylamino acid symmetrical anhydrides : Isolation of two N-acylureas". Int. J. Pept. Protein Res. 43 (2): 184. doi:10.1111/j.1399-3011.1994.tb00521.x.
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