Mouse hepatitis virus
| Mouse hepatitis virus | |
|---|---|
| Virus classification | |
| Group: | Group IV ((+)ssRNA) |
| Order: | Nidovirales |
| Family: | Coronaviridae |
| Subfamily: | Coronavirinae |
| Genus: | Betacoronavirus |
| Species: | Murine coronavirus |
Mouse hepatitis virus is a virus of the family Coronaviridae, genus Betacoronavirus.
The Murine coronavirus, Mouse hepatitis virus (MHV), is a coronavirus that causes an epidemic murine illness with high mortality, especially among colonies of laboratory mice. Prior to the discovery of SARS-CoV, MHV had been the best-studied coronavirus both in vivo and in vitro as well as at the molecular level. Some strains of MHV cause a progressive demyelinating encephalitis in mice which has been used as a murine model for multiple sclerosis. Significant research efforts have been focused on elucidating the viral pathogenesis of these animal coronaviruses, especially by virologists interested in veterinary and zoonotic diseases.
References
- "Mouse Hepatitis Virus (MHV)" (PDF). Division of Animal Resources, University of Illinois, Urbana.
Further reading
- Baker, David G. (1998). "Natural Pathogens of Laboratory Mice, Rats, and Rabbits and Their Effects on Research". Clinical Microbiology Reviews. 11 (2): 231–66. PMC 106832. PMID 9564563.
- Barthold, Stephen W.; Smith, Abigail L. (2006). "Mouse hepatitis virus". In Fox, James; Barthold; Davisson, Muriel; Newcomer, Christian; Quimby, Fred; Smith, Abigail. The mouse in biomedical research: Volume 2 Diseases (2nd ed.). Burlington: Elsevier. pp. 141–178. ISBN 9780080467719.
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