Michael R. Gold

Michael R. Gold, (born August 30, 1956 in New York City, USA) is a Canadian immunologist and cell biologist, head of Head, UBC Department of Microbiology and Immunology, at the University of British Columbia July 2009. He is known for his discovery of how B-cell receptor stimulates Tyrosine phosphorylation and work in the signaling cascade of B-cell receptor.

Biography life

Born and raised in New York City, New York, USA in 1956. He attended the John Bowne High School in Flushing, New York. and then Michigan State University. He was a graduate student at the University of California, Berkeley from 1978-1984, under the supervision of Robert I. Mishell. The goal of his Ph.D. project was to characterize biochemically a receptor present on macrophages, that recognize bacterial peptidoglycan. He then entered a postdoctoral fellowship at the University of California, San Francisco (1985-1991) working on B-cell signalling with Anthony DeFranco, followed by a position as research associate in Ruedi Aebersold’s lab at the Institute for Systems Biology in Seattle, Washington, (1991-1993)

His work led to many important findings, emphasizing the importance of how antigen receptors on the surface of B-cells might trigger the adaptive immunity upon recognizing their cognate antigens

Over a decade, his laboratory has been intensely focusing on how the roles of Rap GTPases in mediating cell mobility, cell migration, tumor motility and metastasis. He is interested in how changes in cytoskeletal structure and function by Rap may affect B-cell receptor activation and signalling cascade. Gold’s publications have been cited more than 6,200 times with the [h-index] of 42.

He is a faculty member of the Department of Microbiology and Immunology at the University of British Columbia, He has been Head of the Department of Microbiology and Immunology since July 2009.

Fellowships and awards

• 2013, Canadian Society for Immunology Cinader Award

Editorships

• Associate editor, Frontiers in B Cell Biology, 2010–present
• Member, Faculty of 1000

Leadership

• Head, UBC Department of Microbiology and Immunology, July 2009-presemt

References

Most Significant Contributions

• Gold, M. R.; Law, D. A.; Defranco, A. L. (1990). "Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor". Nature. 345 (6278): 810–3. doi:10.1038/345810a0. PMID 1694265.

• Durand, C. A.; Hartvigsen, K; Fogelstrand, L; Kim, S; Iritani, S; Vanhaesebroeck, B; Witztum, J. L.; Puri, K. D.; Gold, M. R. (2009). "Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses". The Journal of Immunology. 183 (9): 5673–84. doi:10.4049/jimmunol.0900432. PMID 19843950.

• Lin, K. B.; Freeman, S. A.; Zabetian, S; Brugger, H; Weber, M; Lei, V; Dang-Lawson, M; Tse, K. W.; Santamaria, R; Batista, F. D.; Gold, M. R. (2008). "The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands". Immunity. 28 (1): 75–87. doi:10.1016/j.immuni.2007.11.019. PMID 18191594.

• McLeod, S. J.; Li, A. H.; Lee, R. L.; Burgess, A. E.; Gold, M. R. (2002). "The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): Potential role for Rap2 in promoting B cell migration". Journal of Immunology. 169 (3): 1365–71. doi:10.4049/jimmunol.169.3.1365. PMID 12133960.

• Freeman, S. A.; Lei, V; Dang-Lawson, M; Mizuno, K; Roskelley, C. D.; Gold, M. R. (2011). "Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation". The Journal of Immunology. 187 (11): 5887–900. doi:10.4049/jimmunol.1102233. PMID 22068232.

External links

• The Gold Lab
• Infection, Inflammation and Immunity
• Michael Gold at Google Scholar