2-Hydroxy-3-morpholinopropanesulfonic acid

MOPSO
Names
	IUPAC name 2-hydroxy-3-morpholin-4-ylpropane-1-sulfonic acid[1][2]
	Other names MOPSO, 3-morpholino-2-hydroxypropanesulfonic acid, 3-morpholino-2HOPSA
Identifiers
CAS Number	68399-77-9;
3D model (JSmol)	Interactive image;
EC Number	269-989-6
PubChem CID	109333;
	InChI InChI=1S/C7H15NO5S/c9-7(6-14(10,11)12)5-8-1-3-13-4-2-8/h7,9H,1-6H2,(H,10,11,12) Key: NUFBIAUZAMHTSP-UHFFFAOYSA-N;
	SMILES C1COCCN1CC(CS(=O)(=O)O)O;
Properties
Chemical formula	C7H15NO5S
Molar mass	225.259 g/mol
Appearance	White crystalline powder
Melting point	270–290 °C (518–554 °F; 543–563 K)
Acidity (pKa)	6.9[3]
Hazards
Main hazards	Irritant
GHS signal word	Warning
GHS hazard statements	H315, H319, H335
GHS precautionary statements	P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405, P501
Flash point	Non-flammable
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

MOPSO is a zwitterionic organic chemical buffering agent; one of Good's buffers. MOPSO and MOPS (3-morpholinopropanesulfonic acid) are chemically similar, differing only in the presence of a hydroxyl group on the C-2 of the propane moiety. It has a useful pH range of 6.5-7.9 in the physiological range, making it useful for cell culture work. It has a pKa of 6.9 with ΔpKa/°C of -0.015 and a solubility in water at 0°C of 0.75 M.

MOPSO has been used as a buffer component for:^[4]

Copper analysis via:
- Flow injection micellar technique of the catalytic reaction of 3-methyl-2-benzothiazolinone hydrazone and N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline
- Electrospray ionization quadrupole time-of-flight mass spectroscopy to measure MOPSO-copper chelated complexes
Discontinuous gel electrophoresis on rehydratable polyacrylamide gels
Buffered charcoal yeast extract agar
Fixing cells in urine in a buffered alcohol
Testing crude oil bioremediation products in marine environments

References

↑ "Compound Summary for CID 109333". PubChem. 2005-03-27.
↑ "MOPSO". Sigma-Aldrich.
↑ "Biological Buffers". Sigma-Aldrich.
↑ "MOPSO sodium salt" (PDF). Sigma-Aldrich.

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[1] "Compound Summary for CID 109333". PubChem. 2005-03-27.

[2] "MOPSO". Sigma-Aldrich.

[3] "Biological Buffers". Sigma-Aldrich.

[4] "MOPSO sodium salt" (PDF). Sigma-Aldrich.

2-Hydroxy-3-morpholinopropanesulfonic acid

See also

References