MHC class I polypeptide-related sequence A

MICA
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1B3J, 1HYR
Identifiers
Aliases	MICA, MIC-A, PERB11.1, MHC class I polypeptide-related sequence A
External IDs	GeneCards: MICA
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	31,415,315 bp[1]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• beta-2-microglobulin binding; • protein binding; • natural killer cell lectin-like receptor binding;
Cellular component	• cytoplasm; • integral component of membrane; • membrane; • plasma membrane; • integral component of plasma membrane; • cell surface; • extracellular space;
Biological process	• cytolysis; • adaptive immune response; • negative regulation of natural killer cell activation; • immune system process; • gamma-delta T cell activation; • response to heat; • immune response to tumor cell; • cellular response to DNA damage stimulus; • defense response to bacterium; • defense response to virus; • regulation of immune response; • negative regulation of natural killer cell mediated cytotoxicity; • viral process; • T cell mediated cytotoxicity; • natural killer cell mediated cytotoxicity; • immune response; • natural killer cell activation; • susceptibility to natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	100507436
	n/a
ENSG00000231225; ENSG00000235233; ENSG00000204520; ENSG00000183214; ENSG00000233051;
	n/a
	n/a
	Q29983
	n/a
	NM_001289154; NM_000247; NM_001177519; NM_001289152; NM_001289153
	n/a
	NP_000238; NP_001170990; NP_001276081; NP_001276082; NP_001276083
	n/a
	Wikidata
View/Edit Human

MHC class I polypeptide-related sequence A (MICA) is a cell surface glycoprotein encoded by the MICA gene located within MHC locus.^[3] MICA is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail.^[3] However, MICA is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do.^[4] MICA rather functions as a stress-induced ligand for NKG2D receptor.^[5] For example, the heat shock stress pathway is involved in the regulation of MICA expression as transcription of MICA is regulated by promoter heat shock element.^[4] MICA is broadly recognized by NK cells, γδ T cells, and CD8⁺ αβ T cells which carry NKG2D receptor on their cell surface. As a result of NKG2D-MICA engagement, effector cytolytic responses of T cells and NK cells against epithelial tumor cells expressing MICA are initiated.^[5]

References

1 2 3 ENSG00000235233, ENSG00000204520, ENSG00000183214, ENSG00000233051 GRCh38: Ensembl release 89: ENSG00000231225, ENSG00000235233, ENSG00000204520, ENSG00000183214, ENSG00000233051 - Ensembl, May 2017
↑ "Human PubMed Reference:".
1 2 Bahram S, Bresnahan M, Geraghty DE, Spies T (Jul 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6259–63. doi:10.1073/pnas.91.14.6259. PMC 44180. PMID 8022771.
1 2 Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T (Oct 1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12445–50. doi:10.1073/pnas.93.22.12445. PMC 38011. PMID 8901601.
1 2 Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (Jul 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.

MHC class I polypeptide-related sequence A

See also

References

Further reading