| Hospital Name | Website | Founded |
| Pennsylvania Hospital | http://www.pennmedicine.org/pahosp/ | 1751 |
| Hospital of the University of Pennsylvania | http://www.pennmedicine.org/hospital-university-pennsylvania/ | 1874 |
| Thomas Jefferson University Hospital | http://hospitals.jefferson.edu/ | 1825 |
| Albert Einstein Medical Center | http://www.einstein.edu/ | 1866 |
| Magee Rehabilitation Hospital | http://www.mageerehab.org | 1958 |
| Wills Eye Hospital | http://www.willseye.org/ | 1832 |
| Abington Memorial Hospital | http://www.amh.org/ | 1913 |
| Bryn Mawr Hospital | http://www.mainlinehealth.org/brynmawr | 1893 |
| Aria-Jefferson Health | http://www.ariahealth.org/ | 1902 |
| Chestnut Hill Hospital | http://www.chhealthsystem.com/ | |
| Children's Hospital of Philadelphia | http://www.chop.edu | 1855 |
| Fairmount Behavioral Health System | http://www.fairmountbhs.com | |
| Frankford Hospital (Aria Health) | http://www.frankfordhospitals.org | |
| Mercy Philadelphia Hospital (Mercy Health System) | https://www.mercyhealth.org/locations/mercy-philadelphia | 1918 as Misericordia Hospital |
| Nazareth Hospital (Mercy Health System) | https://www.mercyhealth.org/locations/nazareth-hospital | 1940 |
| Abramson Cancer Center | https://www.pennmedicine.org/cancer | |
| Cancer Treatment Centers of America | http://www.cancercenter.com/eastern/ | 1988 (institution), 2005 (branch) |
| Drexel Internal Medicine Center City | http://www.drexelmedicine.org/ | |
| Friends Hospital | http://friendshospital.com/ | 1813 |
| Hahnemann University Hospital | http://www.hahnemannhospital.com/ | 1885 |
| Jeanes Hospital | http://www.jeanes.com/ | 1928 |
| Methodist Hospital-Jefferson | http://hospitals.jefferson.edu/find-a-location/locations/methodist-hospital/ | |
| Penn Presbyterian Medical Center | http://www.pennmedicine.org/penn-presbyterian-medical-center/ | 1871 |
| Philadelphia VA Medical Center | http://www.philadelphia.va.gov/ | |
| Roxborough Memorial Hospital | http://www.roxboroughmemorial.com/ | 1890 |
| St Joseph's Hospital | http://www.nphs.com/stjo_home.html | 1849 closed 2015 |
| Temple University Hospital | https://tuh.templehealth.org | 1892 as Samaritan Hospital |
| Episcopal Hospital | http://episcopal.templehealth.org/ | |
| St. Christopher's Hospital for Children | https://www.stchristophershospital.com | 1875 |
| Fox Chase Cancer Center | http://www.fccc.edu/ | 1904 |
| Shriners Hospitals for Children | https://www.shrinershospitalsforchildren.org/locations/philadelphia/ | 1922 (institution), 1926 (branch) |