HilD 3'UTR regulatory element
| hilD 3'UTR | |
|---|---|
 Predicted secondary structure and sequence conservation of hilD 3'UTR | |
| Identifiers | |
| Rfam | RF02689 |
| Other data | |
| Domain(s) | Bacteria |
| GO | 0030371 |
| SO | 0005836,0000205 |
| PDB structures | PDBe |
The 3' UTR of mRNA hilD, a master regulator of Salmonella pathogenicity island 1 (SPI-1), is a prokaryotic example of functional 3'UTR. The 3'UTR is a target for hilD mRNA degradation by the degradosome and it may play a role in hilD and SPI-1 expression by serving as a target for the Hfq RNA chaperone. Under non-invasive conditions it is necessary to keep low levels of SPI-1 expression.[1] It plays a role in S. Typhimurium virulence as a regulatory motif.[2]
References
- ↑ López-Garrido, Javier; Puerta-Fernández, Elena; Casadesús, Josep (2014-05-01). "A eukaryotic-like 3' untranslated region in Salmonella enterica hilD mRNA". Nucleic Acids Research. 42 (9): 5894–5906. doi:10.1093/nar/gku222. ISSN 1362-4962. PMC 4027200. PMID 24682814.
- ↑ Gaviria-Cantin, Tania; El Mouali, Youssef; Le Guyon, Soazig; Römling, Ute; Balsalobre, Carlos (2017-04-01). "Gre factors-mediated control of hilD transcription is essential for the invasion of epithelial cells by Salmonella enterica serovar Typhimurium". PLOS Pathogens. 13 (4): e1006312. doi:10.1371/journal.ppat.1006312. ISSN 1553-7374. PMID 28426789.
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