Hippocalcin-like protein 4

HPCAL4
Identifiers
Aliases	HPCAL4, HLP4, hippocalcin like 4
External IDs	MGI: 2157521 HomoloGene: 9441 GeneCards: HPCAL4
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	39,691,689 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	123,194,701 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• calcium ion binding; • calcium channel regulator activity; • protein binding; • metal ion binding; • protein C-terminus binding; • protein domain specific binding;
Cellular component	• intracellular;
Biological process	• central nervous system development; • signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	51440
	170638
	ENSG00000116983
	ENSMUSG00000046093
	Q9UM19
	Q8BGZ1
	NM_016257; NM_001282396; NM_001282397
	NM_174998
	NP_001269325; NP_001269326; NP_057341
	NP_778163
	Wikidata
View/Edit Human	View/Edit Mouse

Hippocalcin like 4, also known as HPCAL4, is a human gene.^[5]

Function

The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. It is a member of the neuronal calcium sensor family.^[6] This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites.^[5]

Kobayashi M, Sakai E, Furuta Y, Takamatsu K (1999). "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes". DNA Sequence. 9 (3): 171–6. doi:10.3109/10425179809072192. PMID 10520747.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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