Syncytin-2

ERVFRD-1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesERVFRD-1, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD, endogenous retrovirus group FRD member 1, endogenous retrovirus group FRD member 1, envelope
External IDsMGI: 3045308 HomoloGene: 86779 GeneCards: ERVFRD-1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p24.2Start11,102,489 bp[1]
End11,111,732 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

405754

239167

Ensembl

ENSG00000244476

ENSMUSG00000047977

UniProt

P60508

Q8BI41

RefSeq (mRNA)

NM_207582

NM_173420

RefSeq (protein)

NP_997465

NP_775596

Location (UCSC)Chr 6: 11.1 – 11.11 MbChr 14: 69.29 – 69.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by the ERVFRD-1 gene.[5] This protein plays a key role in the implantation of human embryos in the womb.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000244476 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047977 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: HERV-FRD HERV-FRD provirus ancestral Env polyprotein".
  6. ↑ Vargas A, Moreau J, Landry S, LeBellego F, Toufaily C, Rassart E, Lafond J, Barbeau B (2009). "Syncytin-2 plays an important role in the fusion of human trophoblast cells". Journal of Molecular Biology. 392 (2): 301–18. doi:10.1016/j.jmb.2009.07.025. PMID 19616006.

Further reading

  • de Parseval N, Lazar V, Casella JF, Benit L, Heidmann T (October 2003). "Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins". Journal of Virology. 77 (19): 10414–22. doi:10.1128/JVI.77.19.10414-10422.2003. PMC 228468. PMID 12970426.
  • Blaise S, de Parseval N, Bénit L, Heidmann T (October 2003). "Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution". Proceedings of the National Academy of Sciences of the United States of America. 100 (22): 13013–8. doi:10.1073/pnas.2132646100. PMC 240736. PMID 14557543.
  • Blaise S, Ruggieri A, Dewannieux M, Cosset FL, Heidmann T (January 2004). "Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians". Journal of Virology. 78 (2): 1050–4. doi:10.1128/JVI.78.2.1050-1054.2004. PMC 368808. PMID 14694139.
  • Renard M, Varela PF, Letzelter C, Duquerroy S, Rey FA, Heidmann T (October 2005). "Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates". Journal of Molecular Biology. 352 (5): 1029–34. doi:10.1016/j.jmb.2005.07.058. PMID 16140326.
  • Malassiné A, Blaise S, Handschuh K, Lalucque H, Dupressoir A, Evain-Brion D, Heidmann T (2007). "Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells". Placenta. 28 (2–3): 185–91. doi:10.1016/j.placenta.2006.03.001. PMID 16714059.
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