Gamma-glutamyltransferase 6

GGT6
Identifiers
Aliases	GGT6, gamma-glutamyltransferase 6
External IDs	MGI: 1918772 HomoloGene: 51918 GeneCards: GGT6
EC number	3.4.19.13
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,556,927 bp[1] End 4,560,818 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 72,435,526 bp[2] End 72,438,400 bp[2]
Gene ontology Molecular function • transferase activity • glutathione hydrolase activity • transferase activity, transferring acyl groups • hydrolase activity • hypoglycin A gamma-glutamyl transpeptidase activity Cellular component • integral component of membrane • extracellular exosome • membrane Biological process • glutathione biosynthetic process • proteolysis • glutathione catabolic process • glutathione metabolic process • leukotriene D4 biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	124975	71522
Ensembl	ENSG00000167741	ENSMUSG00000040471
UniProt	Q6P531	Q6PDE7
RefSeq (mRNA)	NM_153338 NM_001122890 NM_001288702 NM_001288703 NM_001288704	NM_027819
RefSeq (protein)	NP_001116362 NP_001275631 NP_001275632 NP_001275633 NP_699169	NP_082095
Location (UCSC)	Chr 17: 4.56 – 4.56 Mb	Chr 11: 72.44 – 72.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-glutamyltransferase 6 is a protein that in humans is encoded by the GGT6 gene. ^[5]

Function

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.