Daniel Hartl

Daniel L. Hartl (born 1943) is the Higgins biology professor in the Department of Organismic and Evolutionary Biology at Harvard University. He is also a principal investigator at the Hartl Laboratory at Harvard University. His research interests are focused on evolutionary genomics, molecular evolution, and population genetics.[1]

Early life

Hartl was born in 1943 and spent his childhood in Antigo, Wisconsin. He has three brothers and grew up with foster children living in his home. Hartl's father worked in a cheese factory and his mother worked nights as a sous chef.[2]

After high school he enrolled in an extension of the University of Wisconsin–Marathon County in Wausau, Wisconsin. He had just enough money for tuition, and his brothers bought him a car so he could commute the 35 miles to school.[2]

Education

For his graduate school, Hartl attended the University of Wisconsin–Madison.[1] For his doctoral work, Hartl studied Drosophila (a group of insects) and investigated "the mystery of segregation distortion."[2]

He did postdoctoral work at the University of California in Berkeley. Prior to working at Harvard, he held faculty positions at the University of Minnesota, Purdue University, and Washington University in St. Louis.[1]

Research

Hartl began his career studying genetics of segregation distortion in Drosophila[2]. He has published work on population genetic theory, tests of selection,[3] evolution of antimicrobial resistance in E. coli[4] and malaria.[5] His lab identified the Mariner transposon.[6] As of 2017 research at the Hartl Laboratory at Harvard University focused on evolutionary genomics, molecular evolution, and population genetics.[7] Hartl is the author of a widely used textbook on population genetics[8] and an introductory text on genetics.[9]

Published works

  • Daniel L Hartl, Andrew G Clark, Andrew G Clark. Principles of population genetics, 4th ed. 1997. Sinauer Associates (Sunderland, Massachusetts).
  • H Ochman, A S Gerber, D L Hartl. "Genetic applications of an inverse polymerase chain reaction". Genetics. November 1, 1988 vol. 120 no. 3 621-623.
  • Hartl, D. L. A primer of population genetics. 1988. Sinauer Associates (Sunderland, Massachusetts). ISBN 9780878933013.

References

  1. 1 2 3 "Daniel Hartl". hartlgroup.oeb.harvard.edu. Retrieved 2017-01-03.
  2. 1 2 3 4 Tinsley, H. D. (22 May 2007). "Profile of Daniel L. Hartl". Proceedings of the National Academy of Sciences. 104 (22): 9111–9113. doi:10.1073/pnas.0703562104. PMC 1896087.
  3. ↑ Sawyer, S. A.; Hartl, D. L. (1992-12-01). "Population genetics of polymorphism and divergence". Genetics. 132 (4): 1161–1176. ISSN 0016-6731. PMID 1459433.
  4. ↑ Weinreich, Daniel M.; Delaney, Nigel F.; DePristo, Mark A.; Hartl, Daniel L. (2006-04-07). "Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins". Science. 312 (5770): 111–114. doi:10.1126/science.1123539. ISSN 0036-8075. PMID 16601193.
  5. ↑ Park, Daniel J.; Lukens, Amanda K.; Neafsey, Daniel E.; Schaffner, Stephen F.; Chang, Hsiao-Han; Valim, Clarissa; Ribacke, Ulf; Tyne, Daria Van; Galinsky, Kevin (2012-08-07). "Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite". Proceedings of the National Academy of Sciences. 109 (32): 13052–13057. doi:10.1073/pnas.1210585109. ISSN 0027-8424. PMID 22826220.
  6. ↑ Hartl, Daniel L. (2001-02-01). "Discovery of the Transposable Element Mariner". Genetics. 157 (2): 471–476. ISSN 0016-6731. PMID 11156971.
  7. ↑ Hartl, Daniel. "Daniel Hartl". Hartl Laboratory. Harvard University. Retrieved 22 August 2017.
  8. ↑ L., Hartl, Daniel (2007). Principles of population genetics. Clark, Andrew G., 1954- (4th ed.). Sunderland, Mass.: Sinauer Associates. ISBN 0878933085. OCLC 75087956.
  9. ↑ L.,, Hartl, Daniel. Genetics : analysis of genes and genomes. Cochrane, Bruce, (Ninth ed.). Burlington, MA. ISBN 9781284122930. OCLC 996709835.
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