RNA Helicase A

DHX9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LLM, 3VYX, 3VYY
Identifiers
Aliases	DHX9, DDX9, LKP, NDH2, NDHII, RHA, RNA Helicase A, DEAH-box helicase 9, DExH-box helicase 9
External IDs	MGI: 108177 HomoloGene: 1039 GeneCards: DHX9
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 182,839,369 bp[1] End 182,887,751 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G3|1 65.37 cM Start 153,455,758 bp[2] End 153,487,660 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA helicase activity • nucleotide binding • helicase activity • RNA polymerase II transcription factor binding • protein binding • nucleic acid binding • hydrolase activity • RNA binding • DNA binding • single-stranded DNA binding • double-stranded RNA binding • single-stranded RNA binding • nucleoside-triphosphatase activity • chromatin DNA binding • ATP-dependent 3'-5' DNA/RNA helicase activity • ATP-dependent 3'-5' RNA helicase activity • triplex DNA binding • nucleoside-triphosphate diphosphatase activity • importin-alpha family protein binding • single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity • siRNA binding • mRNA binding • ATP-dependent RNA helicase activity • RNA stem-loop binding • polysome binding • promoter-specific chromatin binding • RNA polymerase II core binding • regulatory region RNA binding • RNA polymerase II transcription cofactor activity • RNA polymerase II transcription coactivator activity • DNA replication origin binding • double-stranded DNA binding • ATP-dependent DNA helicase activity • ATP binding • ATPase activity • RNA polymerase binding • core promoter binding • ATP-dependent 3'-5' DNA helicase activity • RISC complex binding • sequence-specific mRNA binding • metal ion binding Cellular component • CRD-mediated mRNA stability complex • cytosol • centrosome • membrane • cytoplasmic ribonucleoprotein granule • cell nucleus • nucleolus • perichromatin fibrils • cytoplasm • nuclear stress granule • micro-ribonucleoprotein complex • nuclear body • intracellular ribonucleoprotein complex • polysomal ribosome • polysome • actin cytoskeleton • protein complex • RISC-loading complex • nucleoplasm • microtubule organizing center • cytoskeleton Biological process • CRD-mediated mRNA stabilization • mRNA splicing, via spliceosome • RNA processing • rhythmic process • protein localization to cytoplasmic stress granule • osteoblast differentiation • positive regulation of type I interferon production • RNA secondary structure unwinding • positive regulation of DNA repair • positive regulation of interferon-beta secretion • positive regulation of transcription from RNA polymerase II promoter • positive regulation of response to cytokine stimulus • cellular response to exogenous dsRNA • positive regulation of interferon-alpha secretion • positive regulation of tumor necrosis factor secretion • positive regulation of interleukin-6 secretion • alternative mRNA splicing, via spliceosome • DNA-templated viral transcription • positive regulation of viral transcription • positive regulation of viral translation • positive regulation of cytoplasmic translation • regulation of transcription from RNA polymerase II promoter • DNA duplex unwinding • positive regulation of DNA replication • positive regulation of fibroblast proliferation • regulation of mRNA processing • positive regulation of NF-kappaB transcription factor activity • cellular response to tumor necrosis factor • positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity • regulation of cytoplasmic translation • targeting of mRNA for destruction involved in RNA interference • positive regulation of interleukin-18 production • G-quadruplex DNA unwinding • positive regulation of innate immune response • positive regulation of RNA export from nucleus • regulation of defense response to virus by host • positive regulation of inflammatory response • pyroptosis • small RNA loading onto RISC • positive regulation of polysome binding • positive regulation of gene silencing by miRNA • immune system process • DNA replication • transcription, DNA-templated • DNA-templated transcription, termination • regulation of transcription, DNA-templated • mRNA processing • regulation of translation • transport • inflammatory response • RNA splicing • gene silencing by RNA • innate immune response • mRNA transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1660	13211
Ensembl	ENSG00000135829	ENSMUSG00000042699
UniProt	Q08211	O70133
RefSeq (mRNA)	NM_001357 NM_030588	NM_007842
RefSeq (protein)	NP_001348	NP_031868
Location (UCSC)	Chr 1: 182.84 – 182.89 Mb	Chr 1: 153.46 – 153.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ATP-dependent RNA helicase A (RHA; also known as DHX9, LKP, and NDHI) is an enzyme that in humans is encoded by the DHX9 gene.^[5][6][7]

Function

DEAD/DEAH box helicases are proteins, and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein with RNA helicase activity. It may participate in melting of DNA:RNA hybrids, such as those that occur during transcription, and may play a role in X-linked gene expression. It contains 2 copies of a double-stranded RNA-binding domain, a DEXH core domain and an RGG box. The RNA-binding domains and RGG box influence and regulate RNA helicase activity.^[7]The DHX9 gene is located on the long arm q of chromosome 1.

Interactions

DHX9 has been shown to interact with:

References

Further reading