Tectitethya crypta

Tectitethya crypta
Scientific classification
Kingdom:	Animalia
Phylum:	Porifera
Class:	Demospongiae
Order:	Hadromerida
Family:	Tethyidae
Genus:	Tectitethya
Species:	T. crypta
Binomial name
	Tectitethya crypta; (de Laubenfels, 1949)
Synonyms[1]
	Cryptotethya crypta de Laubenfels, 1949; Tethya crypta (de Laubenfels, 1949)

Tectitethya crypta (formerly known as Cryptotethya crypta and Tethya crypta) is a species of demosponge belonging to the family Tethyidae.^[1] It is a massive, shallow-water sponge found in the Caribbean Sea.^[2]^[3] Oftentimes, it is covered in sand and algae.^[2]^[3]

The nucleosides spongothymidine and spongouridine were isolated from this sponge, providing the basis for anti-viral drugs and anti-cancer drugs.^[2]^[3] Vidarabine, an antiviral drug, was derived from these compounds.^[4] The discovery of these nucleosides also led to the development of cytarabine for clinical use in the treatment of leukemia and lymphoma.^[5] Gemcitabine, a fluorinated derivative of cytarabine, is used to treat pancreatic, breast, bladder, and non-small-cell lung cancer.^[5]

References

1 2 van Soest, R. (2008). Van Soest RW, Boury-Esnault N, Hooper JN, Rützler K, de Voogd NJ, de Glasby BA, Hajdu E, Pisera AB, Manconi R, Schoenberg C, Janussen D, Tabachnick KR, Klautau M, Picton B, Kelly M, Vacelet J, eds. "Tectitethya crypta (de Laubenfels, 1949)". World Porifera database. World Register of Marine Species. Retrieved 8 April 2017.
1 2 3 Cerrano, Carlo; Pansini, Maurizio; Valisano, Laura; Calcinai, Barbara; Sarà, Michele; Bavestrello, Giorgio (2004). "Lagoon sponges from Carrie Bow Cay (Belize): Ecological benefits of selective sediment incorporation". Bollettino dei Musei e degli Istituti Biologici dell'Università di Genova. 68: 239–252. Retrieved 23 June 2012.
1 2 3 Patricia R. Bergquist (1978). Sponges. University of California Press. p. 205. ISBN 978-0-520-03658-1. Retrieved 23 June 2012.
↑ Sagar, Sunil; Kaur, Mandeep; Minneman, Kenneth P. (2010). "Antiviral lead compounds from marine sponges". Marine Drugs. 8 (10): 2619–2638. doi:10.3390/md8102619. PMC 2992996. PMID 21116410.
1 2 Schwartsmann, G; Brondani da Rocha, A; Berlinck, RG; Jimeno, J (April 2001). "Marine organisms as a source of new anticancer agents". Lancet Oncology. 2 (4): 221–225. doi:10.1016/s1470-2045(00)00292-8. PMID 11905767.

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[WoRMS-1] 1 2 van Soest, R. (2008). Van Soest RW, Boury-Esnault N, Hooper JN, Rützler K, de Voogd NJ, de Glasby BA, Hajdu E, Pisera AB, Manconi R, Schoenberg C, Janussen D, Tabachnick KR, Klautau M, Picton B, Kelly M, Vacelet J, eds. "Tectitethya crypta (de Laubenfels, 1949)". World Porifera database. World Register of Marine Species. Retrieved 8 April 2017.

[Cerrano2004-2] 1 2 3 Cerrano, Carlo; Pansini, Maurizio; Valisano, Laura; Calcinai, Barbara; Sarà, Michele; Bavestrello, Giorgio (2004). "Lagoon sponges from Carrie Bow Cay (Belize): Ecological benefits of selective sediment incorporation". Bollettino dei Musei e degli Istituti Biologici dell'Università di Genova. 68: 239–252. Retrieved 23 June 2012.

[Bergquist1978-3] 1 2 3 Patricia R. Bergquist (1978). Sponges. University of California Press. p. 205. ISBN 978-0-520-03658-1. Retrieved 23 June 2012.

[4] Sagar, Sunil; Kaur, Mandeep; Minneman, Kenneth P. (2010). "Antiviral lead compounds from marine sponges". Marine Drugs. 8 (10): 2619–2638. doi:10.3390/md8102619. PMC 2992996. PMID 21116410.

[pmid11905767-5] 1 2 Schwartsmann, G; Brondani da Rocha, A; Berlinck, RG; Jimeno, J (April 2001). "Marine organisms as a source of new anticancer agents". Lancet Oncology. 2 (4): 221–225. doi:10.1016/s1470-2045(00)00292-8. PMID 11905767.