Cruentaren

Cruentaren is a macrolide secreted by the myxobacteria Byssovorax cruenta .

Two isomers (A and B) have been isolated with a molecular formula of C33H51 NO8 and molecular weight 589. Cruentaren A strongly inhibits the growth of yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines including a multidrug-resistant KB line. Cruentaren B shows only marginal cytotoxicity and no antifungal activity.

References

• Kunze, Brigitte; Heinrich Steinmetz; Gerhard Höfle; Markus Huss; Helmut Wieczorek; Hans Reichenbach (2006). "Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (Myxobacteria) with inhibitory effect on mitochondrial ATPase activity : Fermentation and biological properties". Journal of Antibiotics. 59 (10): 664–668. doi:10.1038/ja.2006.89. ISSN 0021-8820. PMID 17191683.
• "Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases". ScienceDirect. Retrieved 2008-07-07.