Acanthocystis turfacea chlorella virus 1

Acanthocystis turfacea chlorella virus 1
Virus classification
Group: Group I (dsDNA)
Family: Phycodnaviridae
Genus: Chlorovirus
Species

Chlorovirus ATCV-1

Acanthocystis turfacea chlorella virus 1 (ATCV-1), also called Chlorovirus ATCV-1 or Chlorella virus ATCV-1 is a species of giant double-stranded DNA virus in the genus Chlorovirus.

The host of ATCV-1 is Chlorella heliozoae; it was demonstrated that "ATCV-1 neither attaches to nor infects" Chlorella variabilis.[1][2]

Human infection

DNA from ATCV-1 has been isolated from the mucous membranes of the noses of humans. In both humans and mice, the presence of ATCV-1 on the oropharyngeal mucosa was associated with lower scores in tests of cognitive and motor skills.[3][4][5] Injection of purified algal virus ATCV-1 intracranially results in long-lasting cognitive and behavioural effects in mice via induction of inflammatory factors.[6]

References

  1. ↑ Irina Agarkova, Brigitte Hertel, Xinzheng Zhang, Les Lane, Alexander Tchourbanov, David D. Dunigan, Gerhard Thiel, Michael G. Rossmann, James L. Van Etten (2014). "Dynamic attachment of Chlorovirus PBCV-1 to Chlorella variabilis". Virology. 466-467: 95–102. doi:10.1016/j.virol.2014.07.002. PMC 4254200. PMID 25240455 – via Elsevier Science Direct.
  2. ↑ "SAG 211-6 Chlorella variabilis". EPSAG The Culture Collection of Algae at the University of Göttingen, Germany.
  3. ↑ Yolken, R. H.; Jones-Brando, L.; Dunigan, D. D.; Kannan, G.; Dickerson, F.; Severance, E.; Sabunciyan, S.; Talbot, C. C.; Prandovszky, E.; Gurnon, J. R.; Agarkova, I. V.; Leister, F.; Gressitt, K. L.; Chen, O.; Deuber, B.; Ma, F.; Pletnikov, M. V.; Van Etten, J. L. (2014). "Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice". Proc Natl Acad Sci U S A. 111 (45): 16106–11. doi:10.1073/pnas.1418895111. PMC 4234575. PMID 25349393.
  4. ↑ Yolken; et al. (2015). "Reply to Kjartansdóttir et al.: Chlorovirus ATCV-1 findings not explained by contamination". Microbiology. 112 (9): E927. doi:10.1073/pnas.1424665112. PMC 4352770. PMID 25654982.
  5. ↑ Elizabeth Pennisi (27 October 2014), "Algal virus found in humans, slows brain activity", Science
  6. ↑ Marilyn S. Petro, Irina V. Agarkova, Thomas M.Petro (May 2016). "Effect of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice". Journal of Neuroimmunology. 297: 46–55. doi:10.1016/j.jneuroim.2016.05.009. PMID 27397075.
  • "'Acanthocystis turfacea chlorella virus 1". NCBI Taxonomy Browser. 322019.
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