C8 complex
High Resolution Crystal Structure of Human Complement Component 8
| complement component 8, alpha polypeptide | |
|---|---|
| Identifiers | |
| Symbol | C8A |
| Entrez | 731 |
| HUGO | 1352 |
| OMIM | 120950 |
| RefSeq | NM_000562 |
| UniProt | P07357 |
| Other data | |
| Locus | Chr. 1 p36.2-22.1 |
| complement component 8, beta polypeptide | |
|---|---|
| Identifiers | |
| Symbol | C8B |
| Entrez | 732 |
| HUGO | 1353 |
| OMIM | 1209660 |
| RefSeq | NM_000066 |
| UniProt | P073o58 |
| Other data | |
| Locus | Chr. 1 p36.2-22.1 |
| complement component 8, gamma polypeptide | |
|---|---|
| Identifiers | |
| Symbol | C8G |
| Entrez | 733 |
| HUGO | 1354 |
| OMIM | 120930 |
| RefSeq | NM_000606 |
| UniProt | P07360 |
| Other data | |
| Locus | Chr. 9 q34.3 |
Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).
A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.
Membrane attack complex. Some labels are in Polish.
Structure
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.
References
1.J Biol Chem. 2011 May 20;286(20):17585-92. Epub 2011 Mar 25. Figure created in Pymol
External links
- Complement+C8 at the US National Library of Medicine Medical Subject Headings (MeSH)
The crystal structure is now in the PDB, PDB ID 3OJY.
This article is issued from
Wikipedia.
The text is licensed under Creative Commons - Attribution - Sharealike.
Additional terms may apply for the media files.