TMEM242

TMEM242
Identifiers
AliasesTMEM242, BM033, C6orf35, transmembrane protein 242
External IDsMGI: 1917794 HomoloGene: 44020 GeneCards: TMEM242
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q25.3Start157,289,386 bp[1]
End157,323,601 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

729515

70544

Ensembl

ENSG00000215712

ENSMUSG00000004945

UniProt

Q9NWH2

Q8VCR3

RefSeq (mRNA)

NM_018452

NM_027457

RefSeq (protein)

NP_060922

NP_081733

Location (UCSC)Chr 6: 157.29 – 157.32 MbChr 17: 5.41 – 5.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane protein 242 (TMEM242) is a protein that in humans is encoded by the TMEM242 gene.[5]

This protein contains a DUF1358 domain (Domain of Unknown Function 1358).[6]

Domain

The TMEM242 protein has a conserved domain of unknown function pfam 07096, DUF 1358., which covers the first 121 aa of the protein. This domain is conserved in eukaryotes.

Associated Proteins

Several predicted interacting proteins and functional sites on the protein have been identified. One of the predicted interacting protein is MAP2K1IP1, which is a scaffold protein.[7] This protein is known to be involved in the MAP Kinase pathway. The MAP Kinase pathway is associated with the Alzheimer's pathway through a protein called Tau or MAPT. Excessive phosphorylation of this protein leads to aggregation of neurons which can cause Alzheimer's disease.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000215712 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004945 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: chromosome 6 open reading frame 35".
  6. ↑ "Pfam Family: DUF1358 (PF07096)". Pfam. Archived from the original on 2012-08-01.
  7. ↑ C6orf35 protein (Homo sapiens) - STRING interaction network

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


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