FAM114A2

FAM114A2
Identifiers
AliasesFAM114A2, 133K02, C5orf3, family with sequence similarity 114 member A2
External IDsMGI: 1917629 HomoloGene: 10270 GeneCards: FAM114A2
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q33.2Start153,990,128 bp[1]
End154,038,936 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10827

67726

Ensembl

ENSG00000055147

ENSMUSG00000020523

UniProt

Q9NRY5

Q8VE88

RefSeq (mRNA)

NM_018691
NM_001317993
NM_001317994
NM_001317995

NM_001168667
NM_001168668
NM_026342

RefSeq (protein)

NP_001304922
NP_001304923
NP_001304924
NP_061161

NP_001162138
NP_001162139
NP_080618

Location (UCSC)Chr 5: 153.99 – 154.04 MbChr 11: 57.48 – 57.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.

Species Accession # Identity
macaca mulatta XM_001102467 78.1%
Pan troglodytes XM_518045 89.7%
bos taurus NP_001033166 85.6%
Pongo abelii XM_002816109 87.8%
Mus musculus NM_026342.3 79%
Callithrix jacchus XP_002744467 94.7%

Protein

The FAM114A2 protein is 505 amino acids long[5] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.[6] It is predicted to stay in the nucleus after translation [7] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 [8] This protein is thought to include a P loop [9] that suggests a role in ATP- and/or GTP-binding [10]

Gene

The FAM114A2 gene is located on chromosome 5 (5q31-33).[11] This gene has 14 exons spanning through its sequence.[5] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.[5] It is expressed at high levels in most tissues of the human body.[11] It is also highly expressed in tissues in the human brain [12]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000055147 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020523 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 3 Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
  6. ↑ Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#!
  7. ↑ PSORT WWW Server
  8. ↑ STRING: http://string-db.org/newstring_cgi/show_network_section.pl.
  9. ↑ http://string-db.org/newstring_cgi/show_textmining_evidence.pl.
  10. ↑ Saraste M, Sibbald PR, Wittinghofer A (November 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.
  11. 1 2 FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
  12. ↑ Allen Brain Atlas: http://human.brain-map.org/search?type=mi

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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