ATRAID

ATRAID
Identifiers
AliasesATRAID, APR--3, APR-3, APR3, C2orf28, PRO240, p18, HSPC013, all-trans retinoic acid induced differentiation factor
External IDsMGI: 1918918 HomoloGene: 15412 GeneCards: ATRAID
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p23.3Start27,212,027 bp[1]
End27,217,178 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51374

381629

Ensembl

ENSG00000138085

ENSMUSG00000013622

UniProt

Q6UW56

Q6PGD0

RefSeq (mRNA)

NM_080592
NM_001170795
NM_016085

NM_027855
NM_212470

RefSeq (protein)

NP_001164266
NP_057169
NP_542159

NP_082131
NP_997635

Location (UCSC)Chr 2: 27.21 – 27.22 MbChr 5: 31.05 – 31.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Apoptosis-related protein 3 is a protein that in humans is encoded by the ATRAID gene.[5][6][7]

This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138085 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013622 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. ↑ Zhu F, Yan W, Zhao ZL, Chai YB, Lu F, Wang Q, Peng WD, Yang AG, Wang CJ (Nov 2000). "Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes". Biotechniques. 29 (2): 310–3. PMID 10948432.
  7. 1 2 "Entrez Gene: C2orf28 chromosome 2 open reading frame 28".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
  • Yang G, Yu F, Fu H, et al. (2007). "Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB". Mol. Cell. Biochem. 302 (1–2): 187–94. doi:10.1007/s11010-007-9440-7. PMID 17387583.
  • Yu F, Yang G, Zhao Z, et al. (2007). "Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1". Biochem. Biophys. Res. Commun. 358 (4): 1041–6. doi:10.1016/j.bbrc.2007.05.049. PMID 17524364.


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