Bromodifluoroacetyl chloride

Bromodifluoroacetyl chloride
Ball-and-stick model of the bromodifluoroacetyl chloride molecule
Names
Preferred IUPAC name
Bromo(difluoro)acetyl chloride
Other names
2-Bromo-2,2-difluoroacetyl chloride
2-Bromo-2,2-difluoro-ethanoyl chloride
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.197.413
Properties
C2BrClF2O
Molar mass 193.37 g·mol−1
Appearance liquid
Boiling point 50 °C (122 °F; 323 K)
Hazards
Safety data sheet
Corrosive (C)
R-phrases (outdated) R34
S-phrases (outdated) S36/37/39, S45
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Bromodifluoroacetyl chloride is a chemical compound with the formula BrCF2COCl. It has been used as a starting material for the synthesis of (biologically active) α,α-difluoro-γ-lactams[1] and has been used in the synthesis of trifluoromethylated C-nucleosides.[2]

References

  1. ↑ Nagashima, H.; Isono, Y.; Iwamatsu, S. (2001). "Copper-Catalyzed Cyclization of N-Allylhalodifluoroacetamides: An Efficient Synthesis of α,α-difluoro-γ-lactams". Journal of Organic Chemistry. 66 (1): 315–319. doi:10.1021/jo001187f.
  2. ↑ Mamata, C.; Heina, M.; Miethchen, R. (2006). "Fluorinated acyclo-C-nucleoside analogues from glycals in two steps". Carbohydrate Research. 341 (10): 1758–1763. doi:10.1016/j.carres.2006.01.011. PMID 16442508.

See also


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