CDCA8

CDCA8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDCA8, BOR, BOREALIN, DasraB, MESRGP, cell division cycle associated 8
External IDsMGI: 1196274 HomoloGene: 23075 GeneCards: CDCA8
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p34.3Start37,692,418 bp[1]
End37,709,719 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55143

52276

Ensembl

ENSG00000134690

ENSMUSG00000028873

UniProt

Q53HL2

Q8BHX3

RefSeq (mRNA)

NM_018101
NM_001256875

NM_026560

RefSeq (protein)

NP_001243804
NP_060571

NP_080836

Location (UCSC)Chr 1: 37.69 – 37.71 MbChr 4: 124.92 – 124.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Borealin is a protein that in humans is encoded by the CDCA8 gene.[5][6][7]

Function

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[7][8]

Interactions

CDCA8 has been shown to interact with INCENP,[8] Survivin[6][8] and Aurora B kinase.[6][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134690 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028873 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
  6. 1 2 3 Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.
  7. 1 2 "Entrez Gene: CDCA8 cell division cycle associated 8".
  8. 1 2 3 4 Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH (Jan 2005). "Proteome analysis of the human mitotic spindle". Molecular & Cellular Proteomics. 4 (1): 35–43. doi:10.1074/mcp.M400158-MCP200. PMID 15561729.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
  • Vader G, Kauw JJ, Medema RH, Lens SM (Jan 2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody". EMBO Reports. 7 (1): 85–92. doi:10.1038/sj.embor.7400562. PMC 1369225. PMID 16239925.
  • Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P, Wheatley SP (Jan 2006). "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis". The Journal of Biological Chemistry. 281 (2): 1286–95. doi:10.1074/jbc.M508773200. PMID 16291752.
  • Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM (Apr 2006). "Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer". Experimental Cell Research. 312 (7): 962–73. doi:10.1016/j.yexcr.2005.12.015. PMID 16427043.
  • Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH (Apr 2006). "Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres". Molecular Biology of the Cell. 17 (4): 1897–909. doi:10.1091/mbc.E05-08-0727. PMC 1415303. PMID 16436504.
  • Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G (Aug 2006). "Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown". Oncogene. 25 (35): 4867–79. doi:10.1038/sj.onc.1209499. PMID 16547492.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Klein UR, Nigg EA, Gruneberg U (Jun 2006). "Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP". Molecular Biology of the Cell. 17 (6): 2547–58. doi:10.1091/mbc.E05-12-1133. PMC 1474794. PMID 16571674.
  • Kaur H, Stiff AC, Date DA, Taylor WR (2007). "Analysis of mitotic phosphorylation of borealin". BMC Cell Biology. 8: 5. doi:10.1186/1471-2121-8-5. PMC 1794407. PMID 17241471.
  • Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y (May 2007). "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis". Cancer Research. 67 (9): 4113–22. doi:10.1158/0008-5472.CAN-06-4705. PMID 17483322.
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