Bromodomain and WD repeat-containing protein 1

BRWD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRWD1, C21orf107, N143, WDR9, DCAF19, bromodomain and WD repeat domain containing 1, WRD9
External IDsMGI: 1890651 HomoloGene: 23130 GeneCards: BRWD1
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.2Start39,184,176 bp[1]
End39,321,559 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54014

93871

Ensembl

ENSG00000185658

ENSMUSG00000022914

UniProt

Q9NSI6

Q921C3

RefSeq (mRNA)

NM_001007246
NM_018963
NM_033656

NM_001103179
NM_145125
NM_176928

RefSeq (protein)

NP_001007247
NP_061836
NP_387505

NP_001096649
NP_660107
NP_795902

Location (UCSC)Chr 21: 39.18 – 39.32 MbChr 16: 95.99 – 96.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1 gene.[5]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats, and the function of this protein is not known. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000185658 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022914 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: BRWD1 bromodomain and WD repeat domain containing 1".

Further reading

  • Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
  • Huang H, Rambaldi I, Daniels E, Featherstone M (2004). "Expression of the Wdr9 gene and protein products during mouse development". Dev. Dyn. 227 (4): 608–14. doi:10.1002/dvdy.10344. PMID 12889071.
  • Ramos VC, Vidal-Taboada J, Bergoñon S, et al. (2002). "Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21". Biochim. Biophys. Acta. 1577 (3): 377–83. doi:10.1016/s0167-4781(02)00421-9. PMID 12359327.
  • Vidal-Taboada JM, Bergoñón S, Sánchez M, et al. (1998). "High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2". Biochem. Biophys. Res. Commun. 243 (2): 572–8. doi:10.1006/bbrc.1998.8141. PMID 9480850.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.


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