Appendix cancer

Appendix cancer
Classification and external resources
Specialty Oncology
ICD-10 C18.1, C78.5
ICD-9-CM 153.5
MeSH D001063

Appendix cancer or appendiceal cancers are rare malignancies of the vermiform appendix.

Gastrointestinal stromal tumors are rare tumors with malignant potential. Primary lymphomas can occur in the appendix. Breast cancer, colon cancer, and tumors of the female genital tract may metastasize to the appendix.[1]

Treatment

Small carcinoids (<2 cm) without features of malignancy may be treated by appendectomy if complete removal is possible. Other carcinoids and adenocarcinomas may require right hemicolectomy. Note: the term "carcinoids" is outdated: these tumors are now more accurately called "neuroendocrine tumors."[2]

Pseudomyxoma peritonei treatment includes cytoreductive surgery which includes the removal of visible tumor and affected essential organs within the abdomen and pelvis. The peritoneal cavity is infused with heated chemotherapy known as HIPEC in an attempt to eradicate residual disease. The surgery may or may not be preceded or followed with intravenous chemotherapy or HIPEC.[3]

Epidemiology

A study of primary malignacies in the United States found a rate of 0.12 cases per 1,000,000 population per year. Carcinoids that were not identified as malignant were not included in this data.[4] Carcinoid is found in roughly 1 in 300-400 appendectomies for acute appendicitis.[5] A Hong Kong case series of 1492 appendectomies identified 17 neoplasms. Eight were carcinoids without specification of malignant features. Three cases of adenocarcinoma, and one each of cystadenocarcinoma, pseudomyxoma peritoneii, and metastasic carcinoma were identified. The remaining tumors were benign.[6] Carcinoid tumors are the most common tumors of the appendix.[7]

Notable cases

Actress Audrey Hepburn was diagnosed with appendiceal cancer, and she died of the disease in 1993.[8]

In 2007, ESPN sportscast anchor Stuart Scott was diagnosed with appendiceal cancer, and he died of the disease in 2015.[9][10]

Serbian musician Vlada Divljan was diagnosed with the cancer in 2012, and he died of subsequent complications in 2015.[11]

References

  1. ↑ Rosai, Juan (2004) [1953]. "11. Gastrointestinal tract". Rosai and Ackerman's surgical pathology (9th ed.). Mosby. pp. 761–769.
  2. ↑ Griniatsos, J; Michail, O (2010). "Appendiceal neuroendocrine tumors: recent insights and clinical implications". World Journal of Gastrointestinal Oncology. 2 (4): 192–196. doi:10.4251/wjgo.v2.i4.192. PMC 2999180. PMID 21160597.
  3. ↑ M. Townsend, Courtney (2012) [1969]. "51. The appendix". Sabiston (18th ed.). Elsevier. p. 1289.
  4. ↑ McCusker, M. E.; Coté, T. R.; Clegg, L. X.; Sobin, L. H. (2002). "Primary malignant neoplasms of the appendix". Cancer. 94 (12): 3307–3312. doi:10.1002/cncr.10589. PMID 12115365.
  5. ↑ Bailey and Love's Short Practice of Surgery (27th ed.). p. 1315.
  6. ↑ Ma, KW; Chia, NH; Yeung, HW; Cheung, MT (2010). "If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies". Hong Kong medical. 16 (1): 12–7. PMID 20124568.
  7. ↑ Sabiston Principles of Surgery (20th ed.). p. 1308.
  8. ↑ Selim, Jocelyn (Fall 2009), "The Fairest of All", CR, Philadelphia: American Association for Cancer Research, 4 (4), retrieved January 22, 2011
  9. ↑ "Stuart Scott Says, 'F U, Cancer!'". Men's Health. Retrieved 7 January 2015.
  10. ↑ "Stuart Scott, ESPN's Voice of Exuberance, Dies at 49". New York Times. Retrieved 7 January 2015.
  11. ↑ "Vlada Divljan poručio: Nisam životno ugrožen, osećam se vrlo dobro" (in Serbian). Blic. 30 January 2015. Retrieved 10 March 2015.

Further reading

  • Hamilton, S.R.; Aaltonen, L.A., eds. (2000). "Ch. 5 Tumours of the Appendix". World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System (PDF). Lyon: International Agency for Research on Cancer.
  • McGory, Marcia L.; Maggard, Melinda A.; Kang, Hakjung; O'Connell, Jessica B.; et al. (2005). "Malignancies of the appendix: Beyond case series reports". Diseases of the Colon & Rectum. 48 (12): 2264–71. doi:10.1007/s10350-005-0196-4. PMID 16258711.
  • O'Donnell, M.E.; Carson, J.; Garstin, W.I.H. (2006). "Surgical treatment of malignant carcinoid tumours of the appendix". International Journal of Clinical Practice. 61 (3): 431–7. doi:10.1111/j.1742-1241.2006.00875.x. PMID 16911574 – via Medscape.
  • Goede, A.C.; Caplin, M.E.; Winslet, M.C. (2003). "Carcinoid tumour of the appendix". British Journal of Surgery. 90 (11): 1317–22. doi:10.1002/bjs.4375. PMID 14598408.
  • Stinner, B.; Rothmund, M. (2005). "Neuroendocrine tumours (carcinoids) of the appendix". Best Practice & Research: Clinical Gastroenterology. 19 (5): 729–38. doi:10.1016/j.bpg.2005.06.003. PMID 16253897.
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