Amy Wagers

Amy Wagers
Alma mater Johns Hopkins University and Northwestern University
Known for stem cell transplantation experiments
Scientific career
Fields stem cell and regenerative biology, aging biology
Institutions Harvard Medical School
Thesis  (1999)
Website www.scrb.harvard.edu/lab/57/home

Amy J. Wagers is the Forst Family Professor of Stem Cell and Regenerative Biology at Harvard University[1] and Harvard Medical School, an investigator in islet cell and regenerative biology at the Joslin Diabetes Center, and principal faculty of the Harvard Stem Cell Institute.[2]

Education and research

Wager started her education at Johns Hopkins University and received her B.A. in Biological Sciences and her Ph.D. in Immunology and Microbial Pathogenesis from Northwestern University in 1999. She completed her postdoctoral fellowship in the laboratory of Dr. Irving Weissman at Stanford University School of Medicine.[2]

Wagers researches intrinsic and extrinsic regulators of stem cell function and how stem cells impact tissue regeneration and aging. She has demonstrated that transplantation of satellite cells into injured, diseased, or aged muscle can lead to cell engraftment, in some cases restoring muscle function. She has also identified novel regulators (such as EGR1) of stem cell trafficking and stem cell number in bone marrow and during immune responses, and identified blood-borne proteins, such as GDF11, that in mice can reverse some of the pathological changes that occur in aging tissues.[2]

Two publications involving work by a postdoctoral researcher in the Wagers lab in 2008 were retracted by their other authors, one from Nature (2010) and one from Blood (August 2008).[3][4][5] The researcher was dismissed from the lab and later sanctioned by the U.S. Government's Office of Research Integrity (ORI), part of the Department of Health and Human Services.[6]

Personal life

Wagers enjoys trapeze lessons and skydiving.[7]

Awards

References

  1. ↑ "Amy Wagers Principal Investigator Professor". Harvard Department of Stem Cell and Regenerative Biology. Harvard University. Retrieved 1 August 2018.
  2. 1 2 3 4 5 "Amy Wagers, PhD". Harvard Stem Cell Institute.
  3. ↑ Mayack, Shane R.; Shadrach, Jennifer L.; Kim, Francis S.; Wagers, Amy J. (14 October 2010). "Retraction Note to: Systemic signals regulate ageing and rejuvenation of blood stem cell niches". Nature. 467 (7317): 872–872. doi:10.1038/nature09474. Retrieved 1 August 2018.
  4. ↑ Mayack, S. R.; Wagers, A. J. (2 May 2008). "Osteolineage niche cells initiate hematopoietic stem cell mobilization". Blood. 112 (3): 519–531. doi:10.1182/blood-2008-01-133710. PMC 2481533. Retrieved 1 August 2018.
  5. ↑ Wade, Nicholas (October 14, 2010). "3 Harvard Researchers Retract a Claim on the Aging of Stem Cells". The New York Times. Retrieved 1 August 2018.
  6. ↑ Couzin-Frankel, Jennifer (August 30, 2012). "U.S. Misconduct Regulators Sanction Stem Cell Researcher". Science. Retrieved 1 August 2018.
  7. ↑ Chakradhar, Shraddha (2013). "Five Questions for Amy Wagers". Harvard Medicine Magazine. Retrieved 1 August 2018.
  8. ↑ McKeon, David. "Amy Wagers receives New York Stem Cell Foundation-Robertson Stem Cell Prize" (PDF). nyscf.org.
  9. 1 2 3 4 5 "Biographical Sketch OMB No. 0925- 0001/0002 (Rev. 08/12 Approved Through 8/31/2015)" (PDF). Harvard. Retrieved 1 August 2018.
  10. ↑ "Amy J. Wagers". Arnold and Mabel Beckman Foundation. Retrieved 1 August 2018.
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