Asialoglycoprotein receptor 1

ASGR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesASGR1, ASGPR, ASGPR1, CLEC4H1, HL-1, asialoglycoprotein receptor 1
External IDsMGI: 88081 HomoloGene: 1263 GeneCards: ASGR1
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.1Start7,173,431 bp[1]
End7,179,564 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

432

11889

Ensembl

ENSG00000141505

ENSMUSG00000020884

UniProt

P07306

P34927

RefSeq (mRNA)

NM_001197216
NM_001671

NM_001291131
NM_001291132
NM_009714

RefSeq (protein)

NP_001184145
NP_001662

NP_001278060
NP_001278061
NP_033844

Location (UCSC)Chr 17: 7.17 – 7.18 MbChr 11: 70.05 – 70.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Asialoglycoprotein receptor 1 is a protein that in humans is encoded by the ASGR1 gene. [5]

Function

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000141505 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020884 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Asialoglycoprotein receptor 1". Retrieved 2018-10-02.

Further reading

  • Yik JH, Saxena A, Weigel PH (June 2002). "The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes". J. Biol. Chem. 277 (25): 23076–83. doi:10.1074/jbc.M202748200. PMID 11943787.
  • Seow YY, Tan MG, Woo KT (July 2002). "Expression of a functional asialoglycoprotein receptor in human renal proximal tubular epithelial cells". Nephron. 91 (3): 431–8. doi:10.1159/000064283. PMID 12119473.
  • Huang T, Deng H, Wolkoff AW, Stockert RJ (October 2002). "Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones". J. Biol. Chem. 277 (40): 37798–803. doi:10.1074/jbc.M204786200. PMID 12167617.
  • Yik JH, Saxena A, Weigel JA, Weigel PH (October 2002). "Palmitoylation-defective asialoglycoprotein receptors are normal in their cellular distribution and ability to bind ligand, but are defective in ligand uptake and degradation". Biochem. Biophys. Res. Commun. 297 (4): 980–6. PMID 12359251.
  • Yik JH, Weigel PH (December 2002). "The position of cysteine relative to the transmembrane domain is critical for palmitoylation of H1, the major subunit of the human asialoglycoprotein receptor". J. Biol. Chem. 277 (49): 47305–12. doi:10.1074/jbc.M208751200. PMID 12370180.
  • Sørensen AL, Rumjantseva V, Nayeb-Hashemi S, Clausen H, Hartwig JH, Wandall HH, Hoffmeister KM (August 2009). "Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes". Blood. 114 (8): 1645–54. doi:10.1182/blood-2009-01-199414. PMC 2731641. PMID 19520807.
  • Yang J, Wang F, Tian L, Su J, Zhu X, Lin L, Ding X, Wang X, Wang S (June 2010). "Fibronectin and asialoglyprotein receptor mediate hepatitis B surface antigen binding to the cell surface". Arch. Virol. 155 (6): 881–8. doi:10.1007/s00705-010-0657-5. PMID 20364278.
  • Liu J, Hu B, Yang Y, Ma Z, Yu Y, Liu S, Wang B, Zhao X, Lu M, Yang D (September 2010). "A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes". PLoS ONE. 5 (9): e12934. doi:10.1371/journal.pone.0012934. PMC 2944864. PMID 20886072.
  • Zhang X, Lin SM, Chen TY, Liu M, Ye F, Chen YR, Shi L, He YL, Wu LX, Zheng SQ, Zhao YR, Zhang SL (April 2011). "Asialoglycoprotein receptor interacts with the preS1 domain of hepatitis B virus in vivo and in vitro". Arch. Virol. 156 (4): 637–45. doi:10.1007/s00705-010-0903-x. PMID 21207081.


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