5-Fluoroorotic acid

5-Fluoroorotic acid
Names
	IUPAC name 5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid
Identifiers
CAS Number	703-95-7;
3D model (JSmol)	Interactive image;
ChemSpider	62912;
ECHA InfoCard	100.010.798
PubChem CID	69711;
	InChI InChI=1S/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12) Key: SEHFUALWMUWDKS-UHFFFAOYSA-N; InChI=1/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12) Key: SEHFUALWMUWDKS-UHFFFAOYAV;
	SMILES C1(=C(NC(=O)NC1=O)C(=O)O)F;
Properties
Chemical formula	C5H3FN2O4
Molar mass	174.09 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

5-Fluoroorotic acid (5FOA) is a fluorinated derivative of the pyrimidine precursor orotic acid. It is used in yeast genetics to select for the absence of the URA3 gene, which encodes the enzyme for the decarboxylation of 5-fluoroorotic acid to 5-fluorouracil, a toxic metabolite.^[1]

References

↑ "5-Fluoroorotic acid as a selective agent in yeast molecular genetics". 154. 1987: 164–75. PMID 3323810.

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