Eucaine

Eucaine is a chemical that was previously used as a local anaesthetic as an analogue of cocaine. It is a white, crystalline solid.

It can have two forms, alpha-eucaine, or beta-Eucaine (betacain).^[1]^[2] The brand name Betacaine can sometimes refer to a preparation containing lignocaine, not eucaine.

Prior to World War one Britain imported beta-Eucaine from Germany.^[3] During the war a team including Jocelyn Field Thorpe and Martha Annie Whiteley managed to develop a synthesis in Britain.^[3]

Gallery

Eucaine

Alpha-eucaine

Beta-eucaine

Chemical Structures

References

↑ R. H. F. Manske (12 May 2014). The Alkaloids: Chemistry and Physiology. Elsevier. pp. 213–4. ISBN 978-1-4832-2192-2.
↑ Walter Sneader (31 October 2005). Drug Discovery: A History. John Wiley & Sons. pp. 127–9. ISBN 978-0-470-01552-0.
1 2 Creese, Mary RS (1997). "Martha Annie Whiteley (1866-1956): Chemist and Editor" (PDF). Bulletin for the History of Chemistry. 8: 42–45.

External links

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[Manske2014-1] R. H. F. Manske (12 May 2014). The Alkaloids: Chemistry and Physiology. Elsevier. pp. 213–4. ISBN 978-1-4832-2192-2.

[Sneader2005-2] Walter Sneader (31 October 2005). Drug Discovery: A History. John Wiley & Sons. pp. 127–9. ISBN 978-0-470-01552-0.

[Creese1997-3] 1 2 Creese, Mary RS (1997). "Martha Annie Whiteley (1866-1956): Chemist and Editor" (PDF). Bulletin for the History of Chemistry. 8: 42–45.