< Radiation Oncology < Toxicity
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This page is for dosimetric correlations of normal tissue tolerance.
Emami estimates
Normal whole organ tissue tolerances (cGy)(adapted from Emami 1991 PMID 2032882)
| Organ | TD 5/5 | TD 50/5 | ||||
| Whole | 2/3 | 1/3 | Whole | 2/3 | 1/3 | |
| Bladder | 6500 | 8000 | N/A | 8000 | 8500 | N/A |
| Brachial plexus | 6000 | 6100 | 6200 | 7500 | 7600 | 7700 |
| Brain | 4500 | 5000 | 6000 | 6000 | 6500 | 7500 |
| Brainstem | 5000 | 5300 | 6000 | 6500 | – | – |
| Cauda equina | 6000 | – | – | 7500 | – | – |
| Colon (obstruction,perforation,ulceration) | 4500 | – | 5500 | 5500 | – | 6500 |
| Ear (acute serous otitis) | 3000 | 3000 | 3000 | 4000 | 4000 | 4000 |
| Ear (chronic serous otitis) | 5500 | 5500 | 5500 | 6500 | 6500 | 6500 |
| Esophagus (stricture,perforation) | 5500 | 5800 | 6000 | 6800 | 7000 | 7200 |
| Femoral head | 5200 | – | – | 6500 | – | – |
| Heart (pericarditis) | 4000 | 4500 | 6000 | 5000 | 5500 | 7000 |
| Kidney | 2300 | 3000 | 5000 | 2800 | 4000 | – |
| Larynx (necrosis) | 7000 | 7000 | 7900 | 8000 | 8000 | 9000 |
| Larynx (edema) | 4500 | 4500 | – | 8000 | – | – |
| Lens | 1000 | – | – | 1800 | – | – |
| Liver | 3000 | 3500 | 5000 | 4000 | 4500 | 5500 |
| Lung | 1750 | 3000 | 4500 | 2450 | 4000 | 6500 |
| Optic chiasm | 5000 | – | – | 6500 | – | – |
| Optic nerve | 5000 | – | – | 6500 | – | – |
| Parotid gland | 3200 | 3200 | – | 4600 | 4600 | |
| Rectum (severe proctitis,necrosis,fistula,stenosis) | 6000 | – | – | 8000 | – | – |
| Retina | 4500 | – | – | 6500 | – | – |
| Rib cage | – | – | 5000 | – | – | 6500 |
| Skin | (100 cm2) 5500 | (30 cm2) 6000 | (10 cm2) 7000 | (100 cm2) 6500 | – | – |
| Spinal cord | (20 cm) 4700 | (10 cm) 5000 | (5 cm) 5000 | – | (10 cm) 7000 | (5 cm) 7000 |
| Small intestine (obstruction,perforation) | 4000 | – | 5000 | 5500 | – | 6000 |
| Stomach (ulceration,perforation) | 5000 | 5500 | 6000 | 6500 | 6700 | 7000 |
| TMJ mandible | 6000 | 6000 | 6500 | 7200 | 7200 | 7700 |
| Thyroid | 4500 | 8000 |
Partial volume estimates
- See also: Normal tissue complication probability
Emami provides partial volume radiation tolerance estimates for only a few organ sites.
Other researchers' data:
- Full text No PMID — "Use of normal tissue tolerance doses into linear quadratic equation to estimate normal tissue complicatio probability." T. S. Kehwar, Ph.D., D.Sc. and S. C. Sharma, M.D. Radiation Oncology Online Journal (www.rooj.com).
- Tables 3 and 4 are most helpful.
- Full text No PMID — "Analytical approach to estimate normal tissue complication probability using best fit of normal tissue tolerance doses into the NTCP equation of the linear quadratic model." T. S. Kehwar, D.Sc., DABR. Journal of Cancer Research and Therapeutics.
- See especially Table 4
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