Radiation Oncology/CNS/RTOG Brain

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RTOG Website
Wikibooks list of RTOG trials

**Brain/CNS: RTOG OPEN TRIALS**
Number	Site	Title
08-37	GBM	Randomized, Phase II, Double-Blind, Placebo-Controlled Trial of Conventional Chemoradiation and Adjuvant Temozolomide Plus Cediranib Versus Conventional Chemoradiation and Adjuvant Temozolomide Plus Placebo in Patients With Newly Diagnosed Glioblastoma
08-34	Anaplastic Glioma	Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma: The CATNON Intergroup Trial
08-25	GBM	PHASE III DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF CONVENTIONAL CONCURRENT CHEMORADIATION AND ADJUVANT TEMOZOLOMIDE PLUS BEVACIZUMAB VERSUS CONVENTIONAL CONCURRENT CHEMORADIATION AND ADJUVANT TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA
06-27	GBM (recur.)	Phase II Trial of Dasatinib in Patients With Recurrent Glioblastoma Multiforme
06-25	GBM (recur.)	A RANDOMIZED PHASE II TRIAL OF BEVACIZUMAB WITH IRINOTECAN OR BEVACIZUMAB WITH TEMOZOLOMIDE IN RECURRENT GLIOBLASTOMA
06-14	WBRT	A Randomized, Phase III, Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy
06-11	GBM	Urinary VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence
05-39	Meningioma	Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas
05-25	GBM	Phase III Trial Comparing Conventional Adjuvant Temozolomide With Dose-Intensive Temozolomide in Patients With Newly Diagnosed Glioblastoma
03-20 Cancer.gov	Mets	A PHASE III TRIAL COMPARING WHOLE BRAIN RADIATION AND STEREOTACTIC RADIOSURGERY ALONE VERSUS WITH TEMOZOLOMIDE OR ERLOTINIB IN PATIENTS WITH NON-SMALL LUNG CANCER AND 1-3 BRAIN METASTASES
02-27 Cancer.gov	PCNSL	Phase I/II Study of Pre-Irradiation Chemotherapy With Methotrexate, Rituximab, and Temozolomide and Post-Irradiation Temozolomide for Primary Central Nervous System Lymphoma
98-13 Cancer.gov	AA and AOA	A Phase I/III Randomized Study Of Radiation Therapy And Temozolomide (IND #60,265) Versus Radiation Therapy And Nitrosourea For Anaplastic Astrocytoma and Mixed Anaplastic Oligoastrocytoma (Astrocytoma Dominant)	PMID 15234047 (phase I)
98-06	GBM	A Phase II Study of Conventional Radiation Therapy Plus Thalidomide For Supratentorial Glioblastoma

**Brain/CNS: RTOG CLOSED TRIALS**
Number	Site	Title	Publication
05-13 Cancer.gov	GBM	A Phase I/II Trial of Temozolomide, Motexafin Gadolinium, and 60 Gy Fractionated Radiation for Newly Diagnosed Supratentorial Glioblastoma Multiforme	Closed 7/1/2009
04-24 Cancer.gov	LGG	A Phase II Study of Temozolomide-Based Chemoradiotherapy Regimen for High Risk Low-Grade Gliomas	Closed 10/31/2009
04-20 Cancer.gov	GBM	A PHASE II STUDY OF RADIATION THERAPY PLUS LOW DOSE TEMOZOLOMIDE FOLLOWED BY TEMOZOLOMIDE PLUS IRINOTECAN FOR GLIOBLASTOMA MULTIFORME	ASCO 2006
02-11 Cancer.gov	GBM	A PHASE I/II STUDY OF AN ORAL EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR (EGFR-TKI), ZD 1839 (IRESSA), [NSC# 715055] WITH RADIATION THERAPY IN GLIOBLASTOMA MULTIFORME	ASCO 2004 ASCO 2006
01-31 Clinicaltrials.gov	Glioma: AO and Mixed AOA	A Phase II Trial of Pre-Irradiation and Concurrent Temozolomide in Patients with Newly Diagnosed Anaplastic Oligodendrogliomas and Mixed Anaplastic Oligoastrocytomas	PMID 18779504
01-18 Clinicaltrials.gov	Mets	A Phase III Study of Conventional Radiation Therapy Plus Thalidomide (NSC# 66847) Versus Conventional Radiation Therapy for Multiple Brain Metastases	PMID 18164847 PMID 18164829
00-23 Clinicaltrials.gov	GBM	A Phase II Trial of Accelerated Radiotherapy Using Weekly Stereotactic Conformal Boosts For Supratentorial Glioblastoma Multiforme	PMID 16750317
00-21	GBM	A Phase II Trial Of Conventional Radiation Therapy Plus High Dose Tamoxifen For The Treatment Of Supratentorial Glioblastoma Multiforme	PMID 16443947
98-13	AA		PMID 15234047
98-06	Glioma	[Phase II, RT + Thalidomide]
98-03	GBM	Phase I/II Radiation Dose Escalation Study Applying Conformal Radiation Therapy In Supratentorial Glioblastoma Multiforme	PMID 19533025 (QOL) PMID 18723297
98-02 Clinicaltrials.gov	LGG	A Phase II Study of Observation in Favorable Low-Grade Glioma and a Phase III Study of Radiation With or Without PCV Chemotherapy in Unfavorable Low-Grade Glioma	PMID 18976072
97-10	GBM	A phase II study of conventional radiation therapy followed with recombinant interferon beta for supratentorial glioblastoma	ASTRO 2001 PMID 16887285
96-02	Glioma	[Phase II, RT + Taxol]
95-08 Cancer.gov	Mets	A PHASE III TRIAL COMPARING WHOLE BRAIN IRRADIATION WITH VERSUS WITHOUT STEREOTACTIC RADIOSURGERY BOOST FOR PATIENTS WITH ONE TO THREE UNRESECTED BRAIN METASTASES	PMID 15158627
95-07	GBM	Phase I Study of Topotecan plus Cranial Radiotherapy for Glioblastoma Multiforme	PMID 11181676
94-04	AA		PMID 15001257
94-02 Clinicaltrials.gov	AO	Phase III intergroup randomized comparison of radiation alone vs pre-radiation chemotherapy for pure and mixed anaplastic oligodendrogliomas	PMID 11586105 PMID 16782910 PMID 18371182 PMID 19783377 (QOL)
93-10	PCNSL		PMID 16193393
93-05	Glioma	[+/- SRS then RT + BCNU]
91-13	HGG (Recur.)		PMID 9210068
91-10	LGG	A phase III evaluation of postoperative radiation in low grade intracranial astrocytomas and oligodendrogliomas	PMID 11980997 PMID 12829670 (Cognitive) PMID 15964709 (Cognitive)
90-06	Glioma	[BCNU + (HF-RT vs RT)]
90-05	Mets	[Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases]	PMID 8621289 PMID 10802351
85-28	Mets	[Phase I/II trial of accelerated fractionation in brain metastases]	PMID 8330997 PMID 8435812
84-09	Glioma	[Phase I/II WBRT + AZQ]
83-02	HGG	[Phase I/II trial of hyperfractionated and accelerated hyperfractionated radiation therapy with carmustine for adults with supratentorial malignant gliomas]	PMID 1451073 PMID 8380567 PMID 8608540 more..
79-18	Glioma	[WBRT + (BCNU vs Misonidazole + BCNU)]
74-01	HGG	[WBRT 60 Gy vs 60 Gy + 10 Gy boost vs 60 Gy + BCNU vs 60 Gy + BCNU + dacarbazine]	PMID 3281031

Note: Titles are given in brackets when the official protocol title is not known

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